The Interconnectedness of the Global Pandemic

Obesity and cardiometabolic diseases not only trigger a more severe course of COVID-19, SARS-CoV-2 infection can contribute to the development of this condition. Credit: Norbert Stefan

One Nature Views Endocrinology The authors of the article from the German Diabetes Research Center (DZD) emphasize the interaction between obesity and the severity of impaired metabolic health. COVID-19. First, they report an independent relationship between COVID-19 severity, obesity, non-relative fat distribution, and impaired metabolic health. They then discuss the complex mechanisms of COVID-19 and how the disease could affect the global obesity and cardiometabolic pandemic. Finally, they provide recommendations for prevention and treatment in clinical practice and in the public health sector to combat this global pandemic.

Norbert Stefan, Andreas Birkenfeld, and Matthias Schulze summarize and discuss extensive and well-developed data investigating the independent association of obesity with COVID-19 severity. Thus, for the COVID-19 course, they can cut off the contribution of obesity, visceral obesity, and impaired metabolic health. In this regard, they found convincing evidence that obesity and overt diabetes, as well as visceral obesity and even mild hyperglycemia, are important risk factors for disease progression. Thus, these risk factors are likely to have an additional effect on the severity of COVID-19.

Then discuss the effect SARS-CoV-2 Infection of organ function by focusing on cardiometabolically related tissues and organs such as the vascular wall, heart, kidneys, liver, intestines and pancreas. Thus, the immediate damage of COVID-19 to the organs and the long-term effects of the disease, in all likelihood, contribute to the development of obesity and cardiometabolic diseases. Thus, obesity and cardiometabolic diseases not only trigger a more severe course of COVID-19, SARS-CoV-2 infection contributes to the development of these conditions.

The authors highlight how obesity and impaired cardiometabolic health help prevent a serious COVID-19 in patients infected with SARS-CoV-2. In this regard, health workers and policymakers need to promote the health benefits of physical activity more than ever and support efforts to implement programs and policies to facilitate increased physical activity and promote a healthy diet. This may not only be associated with a direct reduction in the incidence and mortality associated with COVID-19 among infected individuals, but may also be important in the context of the SARS-CoV-2 vaccine, in which the response in obese patients should be carefully evaluated. / or diabetes, because there is a potentially reduced or shortened response.

Reference: “Interrelated global pandemics – obesity, impaired metabolic health and COVID-19” by Norbert Stefan, Andreas L. Birkenfeld and Matthias B. Schulze, January 21, 2021, Nature Views Endocrinology.
DOI: 10.1038 / s41574-020-00462-1

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