Improve COVID-19 test sensitivity with Ultra-absorbent Nanofiber Swabs

New nanofiber swab types can enhance sample collection and sensitivity testing for SARS-CoV-2 and other biological specimens; The ruler on the left indicates the centimeter. Credit: Adapted from Nano Letters 2021, DOI: 10.1021 / acs.nanolett.0c04956

Quick, sensitive diagnosis of COVID-19 It is essential for early treatment, tracing contacts and reducing viral transmission. However, some people are affected SARS-CoV-2 receive negative-false test results, which can put the risk and health of others. Currently, researchers report on ACS ‘ Nano Letters has developed ultra-absorbent nanofiber swabs that can reduce the number of false negative tests by increasing sample collection and test sensitivity.

Currently, the most sensitive test for COVID-19 involves using a long swab to collect specimens from deep inside the patient’s nose, then using a method called reverse transcriptase-polymerase chain reaction (RT-PCR) to detect SARS-CoV-2 RNA. But if the viral load is low, which can occur early in the period of infection, the swab is thought to be unable to allow enough viruses to be detected.

Jingwei Xie and colleagues want to develop a nanofiber swab that can absorb and release more viruses and other biological specimens, increasing the sensitivity of diagnostic tests.

Researchers used an electrospinning technique to create a 1 cm long cylinder made of lined nanofiber layers, which were coated with a thin layer of gelatin and fastened to a plastic swab rod.

In laboratory tests, shaft nanofiber tubes absorb and release more proteins, cells, bacteria, DNA and viruses from liquids and surfaces instead of cotton or swabs that are commonly used for COVID-19 testing. The team diluted SARS-CoV-2 virus, wiped the liquid sample and tested for viral RNA by RT-PCR. Compared with the other two types of swabs, nanofiber reduced false negative levels and detected SARS-CoV-2 at a concentration 10 times lower.

In addition to allowing for more accurate and sensitive COVID-19 testing, nanofiber swabs have the potential to diagnose other diseases, test for foodborne illness and help the forensic team identify criminal suspects from miniscule biological specimens, researchers said.

References: “Ultra-absorbent Nanofiber Swabs to Improve Collection and Test Sensitivity of SARS-CoV-2 and Other Biological Specimens” January 26, 2021, Nano Letters.
DOI: 10.1021 / acs.nanolett.0c04956

Related articles

Comments

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Share article

Latest articles

What is cosmic acceleration and dark energy?

as if U.S. Department of Energy February 27, 2021 The universe is expanding, and it is always expanding a little faster. Scientists call this expansion...

Artificial “Magnetic Texture” Caused by Graphene – Can Create Powerful Quantum Computers

The image shows eight electrodes around a 20-nanometer-thick magnet (white rectangle). Graphene does not show a thickness of less than one nanometer and...

LSD provides potentially viable treatment for anxiety and other mental disorders

McGill is studying a step in understanding the mechanism of the impact of psychedelics on the brain and the potential for therapeutic use. Researchers at...

River colors are changing in the United States

1984 - 2018: Over the past 35 years, one-third of the major rivers in the United States have changed their predominant color, often due to...

The crystals found in the stomach of a fossil bird complicate the advice of his diet

Restoration of Bohayornitis Sulkavis, a close relative of Bohayornis Guo, insect hunting. Loan: © S. Abramowicz, Dinosaur Institute, Los Angeles County Museum of...

Newsletter

Subscribe to stay updated.