For field testing of genetically engineered organisms

We need to clarify the terms of the gene engine, or we run the risk of disrupting the industry, confusing the public, losing a technology that can help solve otherwise solvable public health, conservation, and food safety issues. Loan Stephanie Gamez, San Diego

As genetically engineered organisms emerge, the multidisciplinary coalition offers a framework for moral, social inclusion և transparent field practice.

The modern breakthrough in gene engine research, accelerated by CRISPR-Cas9 gene editing technology, has led to transformation waves that are being waved in science.

Genetically engineered genetically engineered (GMOs) with selected traits that have been genetically engineered to spread to the general population have the power to drastically change the way society solves solutions to a range of health and environmental threats, from dengue fever to malaria. against plant pests.

But before these gene-driven organisms can be transferred from the laboratory to field experiments, scientists are offering a course for responsible testing of this powerful technology. These questions are addressed in a new article in the Biotechnology Management Policy Forum. “The main obligations of field testing of genetic motor organisms”, published in 2020. On December 18, Science: by more than 40 researchers, including several scientists from the University of California, San Diego.

“Research has evolved so rapidly through the genetic drive that we are now at a point where we really need to step back and think about how it will affect humanity,” said Akbari, senior author of the article. ենտ Associate Professor, Department of Biological Sciences, UC San Diego. “The new commitments relating to field experiments must ensure that the experiments are carried out safely, transparently, scientifically, politically and socially accountable by the public.”

Release of mosquitoes

The broad coalition, which includes San Diego UC scientists, sets commitments to field testing of powerful gene-driven technology. The multidisciplinary team promotes safe, transparent ethical practice. Loan Stephanie Gamez, San Diego

A multidisciplinary team of gene developers, environmentalists, and environmental biologists has teamed up with social scientists, ethics, and policy experts to outline some of the responsibilities they consider “necessary for responsible field testing” to ensure that these technologies, if available, to invest, to serve the public interest. ” Twelve key commitments have been developed under the following broad categories: Fair partnership և transparency; product efficiency and safety; regulator assessment գնահատում risk / benefit assessment; և monitoring և mitigation.

“Our goal is to facilitate public policy decisions on how to deal with GDOs based on assessments made as a result of a fair and effective partnership with relevant stakeholders and other stakeholders,” the authors write in the article. A signature page for those supporting this effort will be available here.

“This will be an influential piece for the industry, given the number and diversity of co-authors, and will help open up transparent research,” said co-author Kinamon Bloss, UC Associate Professor at Herbert Wertheim School in Sin Diego. public health և human longevity Science:In a recent R01 grant funded by the National Institutes of Health, Bloss will lead a team of San Diego UC researchers on a project to help ensure that these core commitments are embedded in community stakeholder prioritization of the concept in field trials.

“As the authors point out, more needs to be done,” Bloss said. “In particular, I, my co-authors, mainly represent the point of view of North America, therefore, stakeholders from other countries should be included in this conversation, which are more likely to serve as test sites.”

Article co-author Robert Friedman, Cra. Robert Friedman, Craig Venter’s Vice President for University Policy, said the main reason for the effort was the merging of different views of the GDO.

“The variety of perspectives, background and involvement on the issue is really impressive,” Friedman said. “This document includes a multidisciplinary group of developers, environmentalists, ethicists and policy experts, so it includes a wider range of responsibilities than could otherwise have been developed. This, of course, is appropriate, it is necessary for the next significant step, passing from the laboratory to a limited field test. “

Other co-authors of the Department of Biological Sciences at UC San Diego are Associate Professor Kimberly Cooper and Research Assistant Valentino Gantz.

“I think the process of working together over the last few months is worthwhile in itself; I hope these efforts to define our joint commitments will lead to even more discriminatory disciplinary cooperation in the genetic field,” said Kanye Long, first author at UC San Diego Herbert Vertheim Public Health օգ Assistant Doctor of Human Longevity.

What really is the engine of a gene?

At the same time, on December 8, Akbari քանի several co-authors published an article in the National Academy of Sciences (PNAS) on the need to standardize related terms for the basic definition of the gene engine.

To those unfamiliar with science, the rapid growth of gene engine technologies in recent years has come without a set of widely accepted definitions. Without a general agreement on the terms related to the gene engine, confusion and disagreement can arise when gene driving policies and regulations are developed. For example, the authors note that the “gene engine” was used to describe “a process (the biological activity of a gene engine that is prevalent in the population)” or to describe an object (the development of an engineering tool “gene engine”).

“There are a lot of flavors in gene carriers, so it’s really hard for a non-specialist to understand what they’re talking about,” said Akbari, who joined world leaders in gene motors Luke Alfe (PirBright) and Andrea Chrysanti (Imperial College London), Together with Filippo (Fil) Randazzo (Leverage Science), develop definitions. “The purpose of the PNAS article was to bring together leading experts in defining the engine of genes to provide a stable, common language that can be used for communication.”

Working through the National Institutes of Health Foundation (FNIH), Akbari noted that individuals and organizations that comply with the new definition standard become signatories to support those definitions.

Reference. 2020 On December 18, Science:,
DOI: 10.1126 / science.abd1908:

Co-authors: Science: Kanye Long, Luke Alfie, George Lor Anna, Cinnamon Bloss, Carl Campbell, acks Exxon Champer, Chun-Hong Chen, Amit Chudhari, Church Lodge Church, James Ames Collins, Kimberly Cooper, ason Edwin Elm, Delon Kell Robert Friedman, Valentino Gantz, Fred Gould, Sarah Hartley, Elizabeth Haytman, et Annette Hemingway, Hirotaka Kanuka, enn Enifer Kuzma, Lames Levery, Yusuk Lee, Mars Lorenz, Meg Lofen, Ant Yantel Lon , Philippos Aris Papathanos, Prasad Paradkar, Antoinette Piaggio, Jason Rasgon, Gordana Raši ?, Larisa Rudenko, J. Royden Saah, Maxwell Scott, Jolene Sutton, Adam Vorsino and Omar Akbari.

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