Consumption of walnuts causes a change in the function of sperm DNA

Researchers have for the first time evaluated the effect of short / medium-term consumption of a mixture of tree nuts (almonds, hazelnuts և walnuts) on sperm DNA methylation patterns in healthy individuals who reported using a Western-style diet. Loan: © URV

Adding walnuts to the Western style diet affects its epigenetics. This study shows for the first time that there are areas in the sperm cell that respond to diet, which may explain why diet can alter male fertility.

Many environmental factors are involved in the decline of sperm quality, and diet is one of the most likely factors discovered in recent years. Moreover, several studies have reported a close association between unique sperm cell changes DNA: methylation signatures որ sperm quality. To date, however, no randomized clinical trials (RCTs) have been published to evaluate the effects of diet on these changes in sperm DNA function.

Researchers at the University of Utah (led by Dr. Salas-Salvado) Pe University of Utah (led by Dr. Douglas T. Carrell)’s researchers evaluated tree nuts for the first time The effect of short / medium-term consumption of the mixture (almonds, hazelnuts, walnuts) on the DNA methylation patterns of sperm in healthy individuals who reported using a Western-style diet. The analysis was performed as part of the FERTINUTS trial, RCT, led by Dr. Monica Boulogne. Ալ Dr. Albert Salas-Huetos, the results of which were published in 2018. The study found that the inclusion of walnut mixture at 14 weeks significantly improved sperm count, viability, motility and morphology.

This new study was performed on 72 healthy, non-smoking, young participants in the FERTINUTS trial (nut group, n = 48; control group, n = 24) and was recently published in a scientific journal. AndrologyThe researchers found that methylation of 36 genomic regions differed significantly from baseline ից in the nut-only group ավարտ 97.2% of regions showed hypermethylation.

According to the researchers, these findings provide the first evidence that the addition of nuts to a typical Western-style diet affects the methylation of sperm DNA in specific regions.

The first author of the article, Albert Salas-Huetos (who now works at Harvard University, USA), says: in sperm և with the ability to fertilize. ” The researchers also note that the potential health benefits of the results require further study to verify the results found in other populations.

Reference. “Methylation of sperm DNA is altered after short-term walnut supplementation by healthy men on a Western-style diet” by Albert Salas-Huetos, Emma R. James Ames, son of Salas – Salvado, Munica Bulo, Kenneth I. Aston, Douglas T. Carrell and Timothy G. Jenkins, September 23, 2020 Andrology,
DOI: 10.1111 / և 12911:

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